A New Optimization Approach to Distributed Manufacturing System Design
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2025-03-01
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Edition:June 2023 to Dec 2024
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Abstract:This project studies the supply-production-networks (SPNs) in a distributed manufacturing system (DMS) and develops a novel modeling framework and solution procedure for optimizing the production planning and resource allocation decisions in DMS, called centralized-autonomous coordination scheme (CACS). The CACS is able to coordinate the decisions of distributed facilities by optimizing the system-level metrics and respecting the autonomous decisions of individual facilities. Our approach is applied for a case study of a generic drug manufacturer implementing the new continuous manufacturing (CM) technology for active pharmaceutical ingredient (API) production. The results show significant advantages of CACS over the existing approach without centralized coordination.
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Main Document Checksum:urn:sha-512:e2d3483782e7524635f2097e4cfec80f1bca55950f89e2378fa6271f4a0946ce9d8f7c4e1058529cde6c7750560126c61b71b80b8690a0a3ea211243f8aea85b
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