Postmortem Fluid and Tissue Concentrations of THC, 11-OH-THC, and THC-COOH

Angier, Mike K.; Wagner, Jarrad R.; Saenz, Sunday R.; Lewis, Russell J.; United States. Federal Aviation Administration. Office of Aviation Medicine; Oklahoma State University

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Postmortem Fluid and Tissue Concentrations of THC, 11-OH-THC, and THC-COOH

2017-04-01
By Angier, Mike K. ; Wagner, Jarrad R. ; Saenz, Sunday R. ; ...

[PDF-293.23 KB]

English

Details You May Also Like

Details:

Creators:

Angier, Mike K. ; Wagner, Jarrad R. ; Saenz, Sunday R. ; Lewis, Russell J.

Angier, Mike K. ; Wagner, Jarrad R. ; Saenz, Sunday R. ; Lewis, Russell J. Less -
Corporate Creators:

United States. Federal Aviation Administration. Office of Aviation Medicine ; Oklahoma State University

United States. Federal Aviation Administration. Office of Aviation Medicine ; Oklahoma State University Less -
Subject/TRT Terms:

[+]

11-OH-THC Aviation Medicine Aviation Safety Canabiniods Drug Abuse Drug Effects Drug Use Forensic Medicine Forensic Toxicology LC/MS Marijuana Postmortem Distribution THC THC-COOH Toxicology
Publication/ Report Number:

DOT/FAA/AM-17/12
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

United States. Office of Aerospace Medicine
Abstract:

Marijuana is the most commonly abused illicit drug worldwide. Marijuana is used for its euphoric and relaxing properties. However, marijuana use has been shown to result in impaired memory, cognitive skills, and psychomotor function. The Federal Aviation Administration’s Civil Aerospace Medical Institute conducts toxicological analysis on aviation fatalities. Due to severe trauma associated with aviation accidents, blood is not always available; therefore, the laboratory must rely on specimens other than blood for toxicological analysis in approximately 30-40% of cases. However, the postmortem distribution of cannabinoids has not been well characterized. The purpose of this research is to evaluate the distribution of THC, and its metabolites 11-OH-THC, and THC-COOH in postmortem fluid and tissue specimens from 11 fatal aviation accident cases (2014-2015) previously found positive for cannabinoids. Specimens evaluated, when available, included: blood, urine, vitreous humor, liver, lung, kidney, spleen, muscle, brain, heart, and bile. We developed and validated (following SWGTOX guidelines) a sensitive and robust method using solid phase extraction and liquid chromatography-tandem mass spectrometry to identify and quantify THC, 11-OH-THC and THC-COOH in postmortem fluids and tissues. The method readily identified and quantified these cannabinoids in postmortem fluids and tissues below 1 ng/mL. Qualitative cannabinoid results within each case were comparable between blood and non-blood specimens. However, there was no consistent distribution of the cannabinoids between blood and any other fluids or tissues. Therefore, while quantitative interpretation of non-blood specimens is not prudent, a majority of the non-blood specimens tested could be suitable alternative/supplemental choices for qualitative cannabinoid purposes.
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

[+]

urn:sha256:8a1868942d09599dd4a8dd4a0e355909a1f96bc2481aa687541ea69a0a57c4f3
Download URL:

https://rosap.ntl.bts.gov/view/dot/37341/dot_37341_DS1.pdf
File Type:

No Additional Files

More +

Postmortem Fluid and Tissue Concentrations of THC, 11-OH-THC, and THC-COOH

Details:

Supporting Files

You May Also Like