Inhalation Toxicology: XI. The Effect of Elevated Temperature on Carbon Monoxide Toxicity

Sanders, Donald C.; Endecott, Boyd R.

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Inhalation Toxicology: XI. The Effect of Elevated Temperature on Carbon Monoxide Toxicity

1990-12-01
By Sanders, Donald C. ; Endecott, Boyd R.

File Language:

English

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Creators:

Sanders, Donald C. ; Endecott, Boyd R.
Corporate Creators:

Civil Aeromedical Institute
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:

Carbon Monoxide Carbon Monoxide--Physiological Effect--Testing Gases, Asphyxiating And Poisonous--Toxicology Heat Laboratory Animals Laboratory Tests Physiological Aspects Poisonous Gases Rats Rats As Laboratory Animals Toxicity
Publication/ Report Number:

DOT/FAA/AM-90/16
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

Laboratory rats were exposed (a) to experimental concentrations of carbon monoxide in air at ambient temperature, (b) to elevated temperature atmospheres from 40 C to 60° C, and (c) to selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency of each of the environments was evaluated by measurement of time-to-incapacitation (ti) as a function of CO concentration and/or temperature; incapacitation was defined operationally as loss of ability to walk inside a motor-driven, rotating cage enclosed in an exposure chamber. Comparison of data from the combined (CO + elevated temperature) exposures and exposures to CO and elevated temperatures alone indicated that incapacitation occurred earlier when CO inhalation was combined with a whole-body, elevated temperature environment than was observed for the same exposure parameters applied individually. No evidence for a synergistic effect was noted. An empirical equation was derived that allows the calculation of a predicted ti for combinations of CO and temperature within the ranges utilized in the experimental exposures.
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

urn:sha-512:af1b5635492e060f7c736c3c873c449061462c1582e34ed46001712aa396fcf5276b5b917f456fadc7a09198f102eb5018f6bed3f86f1000f14772fe07d3dbbd
Download URL:

https://rosap.ntl.bts.gov/view/dot/21327/dot_21327_DS1.pdf
File Type:

[PDF - 471.63 KB ]

File Language:

English

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