United States Department of Transportation
i
Inhalation Toxicology: XI. The Effect of Elevated Temperature on Carbon Monoxide Toxicity
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1990-12-01
[PDF-471.63 KB]
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Abstract:Laboratory rats were exposed (a) to experimental concentrations of carbon monoxide in air at ambient temperature, (b) to elevated temperature atmospheres from 40 C to 60° C, and (c) to selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency of each of the environments was evaluated by measurement of time-to-incapacitation (ti) as a function of CO concentration and/or temperature; incapacitation was defined operationally as loss of ability to walk inside a motor-driven, rotating cage enclosed in an exposure chamber. Comparison of data from the combined (CO + elevated temperature) exposures and exposures to CO and elevated temperatures alone indicated that incapacitation occurred earlier when CO inhalation was combined with a whole-body, elevated temperature environment than was observed for the same exposure parameters applied individually. No evidence for a synergistic effect was noted. An empirical equation was derived that allows the calculation of a predicted ti for combinations of CO and temperature within the ranges utilized in the experimental exposures.
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