Inhalation Toxicology: XI. The Effect of Elevated Temperature on Carbon Monoxide Toxicity

Details

• Creators:
  Sanders, Donald C. ; Endecott, Boyd R.
• Corporate Creators:
  Civil Aeromedical Institute
• Corporate Contributors:
  United States. Office of Aviation Medicine
• Subject/TRT Terms:
  • Poisonous gases
  • Toxicity
  • Heat
  • Carbon monoxide
  • Physiological aspects
  • Laboratory tests
  • Laboratory animals
  • Rats
  • Gases, Asphyxiating and poisonous--Toxicology
  • Carbon monoxide--Physiological effect--Testing
  More +
• Publication/ Report Number:
  DOT/FAA/AM-90/16
• Resource Type:
  Tech Report
• Geographical Coverage:
  United States
• Corporate Publisher:
  Civil Aerospace Medical Institute
• Abstract:
  Laboratory rats were exposed (a) to experimental concentrations of carbon monoxide in air at ambient temperature, (b) to elevated temperature atmospheres from 40 C to 60° C, and (c) to selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency of each of the environments was evaluated by measurement of time-to-incapacitation (ti) as a function of CO concentration and/or temperature; incapacitation was defined operationally as loss of ability to walk inside a motor-driven, rotating cage enclosed in an exposure chamber. Comparison of data from the combined (CO + elevated temperature) exposures and exposures to CO and elevated temperatures alone indicated that incapacitation occurred earlier when CO inhalation was combined with a whole-body, elevated temperature environment than was observed for the same exposure parameters applied individually. No evidence for a synergistic effect was noted. An empirical equation was derived that allows the calculation of a predicted ti for combinations of CO and temperature within the ranges utilized in the experimental exposures.
• Format:
  PDF
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/21327/dot_21327_DS1.pdf
• File Type:
  [PDF - 471.63 KB]
• Collection(s):
  US Transportation Collection ; FAA Civil Aerospace Medical Institute
• Main Document Checksum:
  urn:sha-512:af1b5635492e060f7c736c3c873c449061462c1582e34ed46001712aa396fcf5276b5b917f456fadc7a09198f102eb5018f6bed3f86f1000f14772fe07d3dbbd