Inhalation Toxicology: X. Times to Incapacitation for Rats Exposed Continuously to Carbon Monoxide, Acrolein, and to Carbon Monoxide-Acrolein Mixtures

Crane, Charles R.; Sanders, Donald C.; Endecott, Boyd R.

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Inhalation Toxicology: X. Times to Incapacitation for Rats Exposed Continuously to Carbon Monoxide, Acrolein, and to Carbon Monoxide-Acrolein Mixtures

1990-12-01
By Crane, Charles R. ; Sanders, Donald C. ; Endecott, Boyd R.

File Language:

English

Details

Creators:

Crane, Charles R. ; Sanders, Donald C. ; Endecott, Boyd R.
Corporate Creators:

Civil Aeromedical Institute
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:
Publication/ Report Number:

DOT/FAA/AM-90/15
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

Laboratory rats were exposed to experimental atmospheres of (a) carbon monoxide (CO) in air, (b) acrolein in air, and (c) to mixtures of CO and acrolein in air. The toxic potency of each of the three types of environments was evaluated toxicokinetically by measurement of time-to-incapacitation (ti) as a function of toxic gas concentrations. Regression equations were derived that relate the observed ti’s to the concentrations of individual gases. Comparison of the combined-gas-exposure data with results obtained from the individual gas exposures indicated that there was no evidence of synergistic action, i.e., that the effect of the combination was never greater than that predicted by the sum of the two individual gas effects. Evidence did exist for an inhibitory or antagonistic effect of undefined mechanism when acrolein was present in the mixture at concentrations of lesser toxic potency than that of CO. An empirical equation was derived that allows the calculation of a predicted ti for combinations of CO and acrolein concentrations within the ranges utilized in the experimental exposures.
Format:

PDF
Download URL:

https://rosap.ntl.bts.gov/view/dot/21325/dot_21325_DS1.pdf
File Type:

[PDF - 1008.64 KB]
Collection(s):

US Transportation Collection ; FAA Civil Aerospace Medical Institute
Main Document Checksum:

urn:sha-512:d1d032df7689aa5faa2d0f9f06324c09048af8a5b09b9f15553d76f42bcdda470756cf4ae6058d4547fa1a25a5c25fa63e1e47aa50eb48651b9b0aa787f91332

File Language:

English

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