Inhalation Toxicology: X. Times to Incapacitation for Rats Exposed Continuously to Carbon Monoxide, Acrolein, and to Carbon Monoxide-Acrolein Mixtures

Crane, Charles R.; Sanders, Donald C.; Endecott, Boyd R.; Civil Aeromedical Institute

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Inhalation Toxicology: X. Times to Incapacitation for Rats Exposed Continuously to Carbon Monoxide, Acrolein, and to Carbon Monoxide-Acrolein Mixtures

1990-12-01
By Crane, Charles R. ; Sanders, Donald C. ; Endecott, Boyd R.

[PDF-1008.64 KB]

English

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Creators:

Crane, Charles R. ; Sanders, Donald C. ; Endecott, Boyd R.

Crane, Charles R. ; Sanders, Donald C. ; Endecott, Boyd R. Less -
Corporate Creators:

Civil Aeromedical Institute
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:

[+]

Acrolein Aircraft Accidents Air Transportation Crashes Carbon Monoxide Fire Gases, Asphyxiating And Poisonous--Toxicology Laboratory Animals Laboratory Tests Poisonous Gases Rats Rats As Laboratory Animals Smoke Smoke--Physiological Effect--Testing Toxicity
Publication/ Report Number:

DOT/FAA/AM-90/15
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

Laboratory rats were exposed to experimental atmospheres of (a) carbon monoxide (CO) in air, (b) acrolein in air, and (c) to mixtures of CO and acrolein in air. The toxic potency of each of the three types of environments was evaluated toxicokinetically by measurement of time-to-incapacitation (ti) as a function of toxic gas concentrations. Regression equations were derived that relate the observed ti’s to the concentrations of individual gases. Comparison of the combined-gas-exposure data with results obtained from the individual gas exposures indicated that there was no evidence of synergistic action, i.e., that the effect of the combination was never greater than that predicted by the sum of the two individual gas effects. Evidence did exist for an inhibitory or antagonistic effect of undefined mechanism when acrolein was present in the mixture at concentrations of lesser toxic potency than that of CO. An empirical equation was derived that allows the calculation of a predicted ti for combinations of CO and acrolein concentrations within the ranges utilized in the experimental exposures.
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

[+]

urn:sha256:1ab8a12252d5fb54b8a873f11e6a39936f0e6453dea98187d4719651e43fda78
Download URL:

https://rosap.ntl.bts.gov/view/dot/21325/dot_21325_DS1.pdf
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Inhalation Toxicology: X. Times to Incapacitation for Rats Exposed Continuously to Carbon Monoxide, Acrolein, and to Carbon Monoxide-Acrolein Mixtures

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