Inhalation Toxicology: VIII. Establishing Heat Tolerance Limits for Rats and Mice Subjected to Acute Exposures at Elevated Air Temperatures

Details

• Creators:
  Crane, Charles R. ; Sanders, Donald C.
• Corporate Creators:
  Civil Aeromedical Institute
• Corporate Contributors:
  United States. Office of Aviation Medicine
• Subject/TRT Terms:
  • Air transportation crashes
  • Physiological aspects
  • Heat transfer
  • Thermal stresses
  • Atmospheric temperature
  • Experiments
  • Laboratory tests
  • Rats
  • Laboratory animals
  • Aircraft accidents
  More +
• Publication/ Report Number:
  DOT/FAA/AM-86/8
• Resource Type:
  Tech Report
• Geographical Coverage:
  United States
• Corporate Publisher:
  Civil Aerospace Medical Institute
• Abstract:
  Experimental animal subjects are used most commonly to assess the toxicity of ; thermal decomposition products (smoke) from burning materials. Nascent smoke is ; obviously quite hot; therefore, the design of smoke toxicity assay systems must ; provide for adequate cooling of the gases prior to exposure of the animals. This ; research has addressed the question of how much cooling is required. ; Rats and mice were exposed to elevated air temperatures over the range of 38 OC to ; 110 OC. The exposure duration required to produce hyperthermic collapse (physical ; incapacitation) was measured for each temperature. A graph of time-to-collapse as ; a function of exposure temperature was constructed for each species and statistically ; derived equations were fit to each data set. Times-to-collapse ranged, for ; the rat, from 60 minutes at 40 OC to less than 4 minutes at 110 OC. For the mouse, ; they ranged from approximately 60 minutes at 40 OC to 2.5 minutes at 90 OC. The ; significance of these findings as they relate to smoke toxicity testing is ; discussed.
  More +
• Format:
  PDF
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/21291/dot_21291_DS1.pdf
• File Type:
  [PDF - 855.37 KB]
• Collection(s):
  US Transportation Collection ; FAA Civil Aerospace Medical Institute
• Main Document Checksum:
  urn:sha-512:cd7cb7df1b365c4dda95242cd813dcec371158c74814a218e833357759cdeb3a05346b70d1690e6e3f1eebc85270a621cb9a9db25bd35a9091d72e4ad993a4bf