United States Department of Transportation
i
Inhalation Toxicology: VIII. Establishing Heat Tolerance Limits for Rats and Mice Subjected to Acute Exposures at Elevated Air Temperatures
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1986-05-01
[PDF-855.37 KB]
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Abstract:Experimental animal subjects are used most commonly to assess the toxicity of
thermal decomposition products (smoke) from burning materials. Nascent smoke is
obviously quite hot; therefore, the design of smoke toxicity assay systems must
provide for adequate cooling of the gases prior to exposure of the animals. This
research has addressed the question of how much cooling is required.
Rats and mice were exposed to elevated air temperatures over the range of 38 OC to
110 OC. The exposure duration required to produce hyperthermic collapse (physical
incapacitation) was measured for each temperature. A graph of time-to-collapse as
a function of exposure temperature was constructed for each species and statistically
derived equations were fit to each data set. Times-to-collapse ranged, for
the rat, from 60 minutes at 40 OC to less than 4 minutes at 110 OC. For the mouse,
they ranged from approximately 60 minutes at 40 OC to 2.5 minutes at 90 OC. The
significance of these findings as they relate to smoke toxicity testing is
discussed.
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