Reactions of Methamidophos with Mammalian Cholinesterase

Details

• Creators:
  Robinson C.P. ; Beiergrohslein D. ; Smith P.W ; Crane C.R.
• Subject/TRT Terms:
  • Insecticides
  • Poisons
  • Physiological aspects
  • Mammals
  • Brain
  • Stomach
  • Blood analysis
  • Toxicity
  • Nervous system
  • Laboratory animals
  More +
• Publication/ Report Number:
  DOT/FAA/AM-78/26
• Resource Type:
  Tech Report
• Geographical Coverage:
  United States
• Corporate Publisher:
  Civil Aerospace Medical Institute
• Abstract:
  The lethality of methamidophos, a phosphoramidothioate, to rats (i.p. LD50, 15 mg/kg), is similar to that of such potent organophosphate compounds as parathion and paraoxon. Certain distinctive features of its chemical structure, and reported failure of cholinesterase inhibited with methamiodophos to reactivate spontaneously in insects, prompted this study of its reactions with mammalian cholinesterase to determine if the treatment of poisoning requires modification. ; Atropine (10 mg/kg) or pralidoxime (60 mg/kg) afforded significant protection against lethality from methamidophos (LD50's, 60 + or - 0.4 and 52 + or - 4.9 mg/kg, respectively). Partial spontaneous recovery of inhibited cholinesterase activity was observed. However, a single dose of pralidoxime, given essentially simultaneously with methamidophos, did not hasten the recovery of cholinesterase activity.
• Format:
  PDF
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/21136/dot_21136_DS1.pdf
• File Type:
  [PDF - 377.72 KB]
• Collection(s):
  FAA Civil Aerospace Medical Institute ; US Transportation Collection
• Main Document Checksum:
  urn:sha-512:1eed15a04540c3e741eda78cdc9277598c237d376ac326226a6d6aa215af3b01ad1ba622aa21cf0b981f388d428aeeac406bfd95ad40293c68c4d0f1bac20422