Reactions of Methamidophos with Mammalian Cholinesterase

Robinson C.P.; Beiergrohslein D.; Smith P.W; Crane C.R.

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Reactions of Methamidophos with Mammalian Cholinesterase

1978-07-01
By Robinson C.P. ; Beiergrohslein D. ; Smith P.W ; ...

[PDF-377.72 KB]

English

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Creators:

Robinson C.P. ; Beiergrohslein D. ; Smith P.W ; Crane C.R.

Robinson C.P. ; Beiergrohslein D. ; Smith P.W ; Crane C.R. Less -
Subject/TRT Terms:

[+]

Atropine Blood--Analysis Blood Analysis Brain Cholinesterase-inhibiting Insecticides Experiments Insecticides Insecticides--Physiological Effect Insecticides--Toxicology Laboratory Animals Mammals Nervous System Organophosphorus Compounds Physiological Aspects Poisons Rats Stomach Toxicity
Publication/ Report Number:

DOT/FAA/AM-78/26
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

The lethality of methamidophos, a phosphoramidothioate, to rats (i.p. LD50, 15 mg/kg), is similar to that of such potent organophosphate compounds as parathion and paraoxon. Certain distinctive features of its chemical structure, and reported failure of cholinesterase inhibited with methamiodophos to reactivate spontaneously in insects, prompted this study of its reactions with mammalian cholinesterase to determine if the treatment of poisoning requires modification.

Atropine (10 mg/kg) or pralidoxime (60 mg/kg) afforded significant protection against lethality from methamidophos (LD50's, 60 + or - 0.4 and 52 + or - 4.9 mg/kg, respectively). Partial spontaneous recovery of inhibited cholinesterase activity was observed. However, a single dose of pralidoxime, given essentially simultaneously with methamidophos, did not hasten the recovery of cholinesterase activity.
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PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

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urn:sha256:7ad1f7f46e7f7db1aa9a3cc7f225cd45dfcbf56a3ad0c3fd5bede88a88d36c2b
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https://rosap.ntl.bts.gov/view/dot/21136/dot_21136_DS1.pdf
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Reactions of Methamidophos with Mammalian Cholinesterase

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