Mechanisms of action of the insecticide endrin.

Details

• Creators:
  Emerson, Thomas E. ; Brake, Charles M. ; Hinshaw, Lerner B.
• Corporate Creators:
  Civil Aeromedical Research Institute
• Subject/TRT Terms:
  • Air pilots
  • Insecticides
  • Poisons
  • Cardiovascular system
  • Arteries
  • Nervous system
  • Brain
  • Spinal cord
  • Laboratory animals
  • Dogs
  More +
• Publication/ Report Number:
  AM 63-16 ; DOT/FAA/AM-63/16
• Resource Type:
  Tech Report
• Geographical Coverage:
  United States
• Corporate Publisher:
  Civil Aerospace Medical Institute
• Abstract:
  Cardiovascular effects of endrin insecticide are obscure. Experiments to investigate this phenomenon were carried out on dogs and suggested mechanisms of actions have been proposed. Results show that acute administration of endrin produces bradycardia, hypertension, copious salivation, tonic-clonic convulsions, increased body temperature, leukocytosis, hemoconcentrations and decreased blood pH. ; Cerebral venous pressure and cerebrospinal fluid pressure elevations are also prominent features of endrin poisoning. Although most of these effects appear to be caused by endrin acting directly on the central nervous system some may result secondarily from altered cerebral hemodynamics.
• Format:
  PDF
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/20859/dot_20859_DS1.pdf
• File Type:
  [PDF - 672.40 KB]
• Collection(s):
  FAA Civil Aerospace Medical Institute ; US Transportation Collection
• Main Document Checksum:
  urn:sha-512:32c104ea018480760a6bc9bb5e588423d3c8368471433bcfecccb7ac65381a2eaeeff5cbd2d3e431496803b68e255f0d44ab14622dfc95812ab65671f4ff6d39