Effects of two antihistamine-containing compunds upon performance at three altitudes.

Details

• Creators:
  Higgins, E. Arnold ; Davis, Audie W. ; Fiorica, Vincent ; Iampietro, P.F. ; Vaughan, John A. ; Funkhouser, Gordon E.
• Corporate Creators:
  United States. Office of Aviation Medicine
• Subject/TRT Terms:
  • Air pilots
  • Antihistamines
  • Physiological aspects
  • Altitude
  • Performance
  • Drug effects
  • Placebos
  • Heart rate
  • Temperature
  • Blood analysis
  More +
• Publication/ Report Number:
  AM 68-15 ; DOT/FAA/AM-68/15
• Resource Type:
  Tech Report
• Geographical Coverage:
  United States
• Corporate Publisher:
  Civil Aerospace Medical Institute
• Abstract:
  In a study of 45 human subjects it was determined that a compound drug containing the antihistamine phenindamine did not statistically impair performance on a modified Mashburn coordinator. Another compound containing the antihistamine chlorpheniramine did impair performance. Performance was also impaired by increasing altitudes. The combined effects of the chlorpheniramine compound and increased altitude proved more detrimental to performance than the sum of the decrements that each influence caused when encountered separately. Although no significant performance decrement resulted from the administration of the phenindamine compound, undesirable side-effects were noted.
• Format:
  PDF
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/20854/dot_20854_DS1.pdf
• File Type:
  [PDF - 1.57 MB]
• Collection(s):
  FAA Civil Aerospace Medical Institute ; US Transportation Collection
• Main Document Checksum:
  urn:sha-512:0eea8a2319edfce7acd16b663afa4e5e780171c55a1eab3b47c4d4e0c38f51a49a466322dbb53311087f1b60184e349eebe6c49435c5e49730d5e2fff05b0f0e