The effects of dextroamphetamine on physiological responses and complex performance during sleep loss.

Higgins, E.A.; Chiles, W.D.; McKenzie, J.M.; Iampietro, P.F.; Vaughan, J.A.; Funkhouser, G.E.; Burr, M.J.; Jennings, A.E.; West, G.; Civil Aeromedical Institute

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The effects of dextroamphetamine on physiological responses and complex performance during sleep loss.

1975-11-01
By Higgins, E.A. ; Chiles, W.D. ; McKenzie, J.M. ; ...

[PDF-756.55 KB]

English

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Creators:

Higgins, E.A. ; Chiles, W.D. ; McKenzie, J.M. ; Iampietro, P.F. ; Vaughan, J.A. ; ... More +

Higgins, E.A. ; Chiles, W.D. ; McKenzie, J.M. ; Iampietro, P.F. ; Vaughan, J.A. ; Funkhouser, G.E. ; Burr, M.J. ; Jennings, A.E. ; West, G. Less -
Corporate Creators:

Civil Aeromedical Institute
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:

[+]

Adrenaline Alertness Amines Amphetamines Body Temperature Catecholamines Drug Effects Drugs--Physiological Effect Experiments Fatigue Fatigue (Physiological Condition) Heart Beat Heart Rate Human Subject Testing Noradrenaline Performance Physiological Aspects Sleep Sleep Deprivation Temperature Urine Urine--Analysis
Publication/ Report Number:

FAA-AM-75-14 ; DOT/FAA/AM-75/14

FAA-AM-75-14 ; DOT/FAA/AM-75/14 Less -
Resource Type:

Tech Report
Geographical Coverage:

United States
Edition:

OAM report.
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

On two separate occasions, performance of 10 male subjects was measured on the Civil Aeromedical Institute Multiple Task Performance Battery at 4-hour intervals for a period of 24 hours without sleep. Each subject received a capsule at 4-hour intervals beginning at 2000. On one occasion, the first three doses contained 5 mg each of dextroamphetamine sulfate followed by placebos for the remaining three capsules. On the other occasion, all capsules were placebos.

Results of the experiment demonstrated that the dextroamphetamine sulfate sustained a high level of proficiency and alertness and delayed the effects of fatigue for 8 to 12 hours after the ingestion of the third and final drug capsule. Heart rate, rectal temperature, and urinary excretion rates of catecholamines were elevated with this drug. These increases could support the enhancement of proficiency and alertness demonstrated with amphetamines. Neither the subjects' feelings of fatigue nor the accuracy of their estimates of performance capabilities differed significantly in these two test conditions.
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

[+]

urn:sha256:585af4788618a23ffb6436b94d6a163c169394e319161296280078dea6844584
Download URL:

https://rosap.ntl.bts.gov/view/dot/21072/dot_21072_DS1.pdf
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The effects of dextroamphetamine on physiological responses and complex performance during sleep loss.

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