Problems in aerial application : a comparison of the acute effects of endrin and carbon tetrachloride on the livers of rats and of the residual effects one month after poisoning.

Clark, George; United States. Office of Aviation Medicine

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Problems in aerial application : a comparison of the acute effects of endrin and carbon tetrachloride on the livers of rats and of the residual effects one month after poisoning.

1966-07-01
By Clark, George

[PDF-744.69 KB]

English

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Details:

Creators:

Clark, George
Corporate Creators:

United States. Office of Aviation Medicine
Subject/TRT Terms:

[+]

Aerial Application Air Pilots Carbon Tetrachloride Endrin--Physiological Effect Experiments Hydrocarbons Insecticides Internal Organs Laboratory Animals Liver Pest Control Baits--Aerial Application Physiological Aspects Poisons Rats Rats As Laboratory Animals RNA Stains And Staining (Microscopy) Toxicity Testing Toxicology
Publication/ Report Number:

AM 66-34 ; DOT/FAA/AM-66/34

AM 66-34 ; DOT/FAA/AM-66/34 Less -
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

A comparison was made of the effects on the liver of carbon tetrachloride and of endrin. Rats poisoned with either endrin or carbon tetrachloride were studied in the acute stage and after a one month recovery period. With endrin, fat was deposited perilobularly in relatively fine droplets, RNA was diffuse perilobularly and was in clumps elsewhere and the density of the Weil stain was increased in acutely poisoned rats.

By contrast, the fat was centrolobular in CC14 poisoned animals, there was little change in RNA except for its absence in necrotic cells and the density of the Weil stain was only slightly greater than in the controls. In the one month recovery period, all changes seen in the acute animals virtually disappeared and histologically the livers were almost normal.
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

[+]

urn:sha256:dd2427887223d71ecd900f8f9e2d3169897a9e6c770fa923fcf50093ed237add
Download URL:

https://rosap.ntl.bts.gov/view/dot/20803/dot_20803_DS1.pdf
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Problems in aerial application : a comparison of the acute effects of endrin and carbon tetrachloride on the livers of rats and of the residual effects one month after poisoning.

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