Problems in aviation personnel : influence of a tranquilizer on temperature regulation in man.

Iampiertro, P.F.; Fiorica, V.; Dille, J.R.; Higgins, E.A.; Funkhouser, G.; Moses, R.; United States. Office of Aviation Medicine

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Problems in aviation personnel : influence of a tranquilizer on temperature regulation in man.

1966-05-01
By Iampiertro, P.F. ; Fiorica, V. ; Dille, J.R. ; ...

[PDF-465.24 KB]

English

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Creators:

Iampiertro, P.F. ; Fiorica, V. ; Dille, J.R. ; Higgins, E.A. ; Funkhouser, G. ; ... More +

Iampiertro, P.F. ; Fiorica, V. ; Dille, J.R. ; Higgins, E.A. ; Funkhouser, G. ; Moses, R. Less -
Corporate Creators:

United States. Office of Aviation Medicine
Subject/TRT Terms:

[+]

Air Pilots Amines Blood Analysis Blood Plasma--Analysis Body Temperature--Regulation--Effect Of Drugs On Catecholamines Drug Effects Experiments High Temperature High Temperatures Human Subject Testing Low Temperature Low Temperatures Physiological Aspects Placebos Placebos (Medicine) Respiration Respiratory System Temperature Thermal Stresses Tranquilizers Tranquilizing Drugs
Publication/ Report Number:

AM 66-14 ; DOT/FAA/AM-66/14

AM 66-14 ; DOT/FAA/AM-66/14 Less -
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

The effects of a tranquilizing drug of the propaediol group, meprobamate, on thermal balance of men exposed to a cold (50F, 10C), hot (110F, 43.3C), or neutral (80F, 26.7C) environment have been investigated. Results show that a single dose of meprobamate (800 mg) has no effect on temperature regulation of men resting in a neutral environment.

During exposure to hot or cold environments, however, the drug groups showed impairment in thermal balance. In the cold, heat production and core temperature of the drug group were lower than the placebo group. In the heat, only moderate elevations in the core temperatures of the drug group were detected. Possible physiological mechanisms responsible for these differences are discussed.
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PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

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urn:sha256:435420166632c85baf917dbf6f95168dd60ead91902f905e578d100e50ad7173
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https://rosap.ntl.bts.gov/view/dot/20783/dot_20783_DS1.pdf
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Problems in aviation personnel : influence of a tranquilizer on temperature regulation in man.

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