United States Department of Transportation
i
Problems in Aerial Application: I. - V.
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1966-06-01
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[PDF-2.00 MB]
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Abstract:Airmen who apply insecticides from aircraft may suffer ill-defined effects from continued exposure to insecticide particles suspended in the air medium. The present series of experiments has been designed to study both lethal and sublethal effects resulting from contact with the chlorinated hydrocarbon insecticide endrin. A large variety of experiments has been performed, aimed at uncovering mechanisms operative primarily in the cardiovascular system. Results from experiments completed in several hundred dogs indicate that endrin elicits prominent cardiovascular effects due to central-nervous-system intoxication. The complex chain of events occurring within 30 minutes after introduction of endrin into the blood stream includes a generalized violent activation of the sympathoadrenal system. Virtually every vascular bed exhibits prominent changes in pressures, blood flow, and resistances; however, toxic actions on specific tissues could not be established by gross and histological analyses. Increased knowledge of how chemical agents such as endrin act on various organs will provide valuable medical guidelines governing the treatment of individuals occupationally exposed during aerial- applicator work.
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