Instrumentation Development for Drug Detection on the Breath

Details

• Creators:
  Hobbs, J. R. ; Barrington, A. E.
• Corporate Creators:
  John A. Volpe National Transportation Systems Center (U.S.)
• Corporate Contributors:
  United States. National Highway Traffic Safety Administration
• Subject/TRT Terms:
  • Drug tests
  • Detectors
  • Drugs
  • Equipment tests
  • Mass spectrometry
• Publication/ Report Number:
  DOT-HS-820-253 ; DOT-TSC-NHTSA-72-9 ; NTIS-PB220168
• DOI:
  https://doi.org/10.21949/1524855
• Resource Type:
  Research Paper
• Geographical Coverage:
  United States
• Corporate Publisher:
  United States. National Highway Traffic Safety Administration
• Description:
  Based on a survey of candidate analytical methods, mass spectrometry was identified as a promising technique for drug detection on the breath. To demonstrate its capabilities, an existing laboratory mass spectrometer was modified by the addition of a membrane separator and a field-ionization source. Fourteen drugs were selected for investigation and it was possible to identify the signatures (mass spectra) of ten of these drugs with the modified instrument. Some drugs have been detected by direct sniffing, other first had to be dissolved in a suitable solvent and evaporated. The mass spectra presented in the report indicate the basic simplicity of field ionization as compared with ionization by the conventional method of electron impact. The report concludes with a description of the ease and rapidity of the new technique for clinical analysis. /Abstract from summary report page/
• Format:
  PDF
• Funding:
  DOT-HS-302
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/1080/dot_1080_DS1.pdf
• File Type:
  [PDF - 1.14 MB]
• Collection(s):
  NHTSA - Behavioral Safety Research ; Volpe Center
• Main Document Checksum:
  urn:sha256:f3b1825a9f0d13c884348c9a3b97b73115de324d955976735753ec34bb7337a0