Instrumentation Development for Drug Detection on the Breath
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1972-09-01
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Abstract:Based on a survey of candidate analytical methods, mass spectrometry was identified as a promising technique for drug detection on the breath. To demonstrate its capabilities, an existing laboratory mass spectrometer was modified by the addition of a membrane separator and a field-ionization source. Fourteen drugs were selected for investigation and it was possible to identify the signatures (mass spectra) of ten of these drugs with the modified instrument. Some drugs have been detected by direct sniffing, other first had to be dissolved in a suitable solvent and evaporated. The mass spectra presented in the report indicate the basic simplicity of field ionization as compared with ionization by the conventional method of electron impact. The report concludes with a description of the ease and rapidity of the new technique for clinical analysis. /Abstract from summary report page/
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