United States Department of Transportation
i
Postmortem Blood Genomics Biorepository
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2024-08-01
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[PDF-655.53 KB]
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Abstract:The Federal Aviation Administration Civil Aerospace Medical Institute Bioaeronautical Sciences Research Laboratory (BSRL) collects, processes, and analyzes forensic fluid and tissue samples from fatal civil aviation accidents in the United States. The BSRL issues standardized forensic sample collection kits (ToxBoxes) for medical examiners and coroners to collect and ship the samples needed for toxicological analysis. The BSRL Forensic Sciences section receives and assays incoming forensic samples to determine if the pilot consumed or was exposed to known drugs or toxic substances. This information is collected on behalf of the National Transportation Safety Board to assist in accident investigation. The BSRL Functional Genomics Research team previously examined gene expression patterns in such forensic samples. However, ToxBox forensic samples were not routinely preserved in a manner that prevented the degradation of those patterns during collection and storage. This report details establishment of protocols and selection of tubes to supplement ToxBox collections with preservation of blood for functional genomics analyses. To preserve ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) in forensic samples and establish a biorepository of samples suitable for future gene expression analyses, a supplemental whole blood research specimen collection kit is now included in ToxBoxes. These kits have been distributed in ToxBoxes since August 2022.
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