Regulation of gene expression is a complex process that exquisitely responds to the environment to maintain cellular and, ultimately, organismal homeostasis. Gene expression research is undertaken at the Federal Aviation Administration as a means of discovering sets of biomarkers that change in response to environmental factors that affect aviation safety. This article reviews mechanisms of gene regulation and discusses how genomics is changing the way medicine is practiced today as a means of demonstrating that molecular medicine is here to stay. Next, the protocols that have been developed into a cohesive workflow to perform gene expression analysis are presented. Environmental factors currently under investigation are delineated, followed by a discussion of other factors of interest for future research. We believe this research will benefit the aviation industry by improving the accuracy of the data used to write regulation, thus improving the already remarkable safety record of the aviation industry and decreasing medical risks to flight crew.
Gene expression changes resulting from conditions such as disease, environmental stimuli, and drug use can be monitored in the blood. However, a less ...
In its 1990 recommendation regarding occupational exposure during pregnancy, the International Commission on Radiological Protection apparently assume...
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