United States Department of Transportation
Functional Genomics Group – Program Description
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2008-02-01
File Language:
English
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Abstract:Regulation of gene expression is a complex process that exquisitely responds to the environment to maintain cellular and, ultimately, organismal homeostasis. Gene expression research is undertaken at the Federal Aviation Administration as a means of discovering sets of biomarkers that change in response to environmental factors that affect aviation safety. This article reviews mechanisms of gene regulation and discusses how genomics is changing the way medicine is practiced today as a means of demonstrating that molecular medicine is here to stay. Next, the protocols that have been developed into a cohesive workflow to perform gene expression analysis are presented. Environmental factors currently under investigation are delineated, followed by a discussion of other factors of interest for future research. We believe this research will benefit the aviation industry by improving the accuracy of the data used to write regulation, thus improving the already remarkable safety record of the aviation industry and decreasing medical risks to flight crew.
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[PDF - 948.72 KB] -
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Main Document Checksum:urn:sha256:2669ca82734e70d67abd8a6d4ec9f856d2c37e2f53f356b6ac76bd849a44a4bd
File Language:
English
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