The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident

White, Vicky; Canfield, Dennis V.; Hordinsky, Jerry R.; Civil Aeromedical Institute

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The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident

1992-07-01
By White, Vicky ; Canfield, Dennis V. ; Hordinsky, Jerry R.

[PDF-773.58 KB]

English

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Creators:

White, Vicky ; Canfield, Dennis V. ; Hordinsky, Jerry R.

White, Vicky ; Canfield, Dennis V. ; Hordinsky, Jerry R. Less -
Corporate Creators:

Civil Aeromedical Institute
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:

[+]

Aircraft Accidents Air Pilots Air Transportation Crashes Blood--Analysis Blood Analysis Drug Effects Drugs--Physiological Effect Drug Tests Gas Chromatography Hypertension Triamterene Urinalysis Urine--Analysis
Publication/ Report Number:

DOT/FAA/AM-92/23
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

Triamterene, a diuretic drug used in combination with other drugs for the treatment of hypertension, was found in the blood and urine of a fatal aircraft accident victim. The extraction and identification of triamterene is difficult. It exhibits poor extraction efficiency using some standard base extraction procedures and the parent drug is unsuitable for analysis using gas chromatography. In this case a thin layer chromatography solvent system and high performance liquid chromatography were used to identify and quantitate triamterene in blood and urine. Triamterene is a strong absorber in the ultraviolet region and has an unusual UV spectrum, which simplifies the identification and quantitation of this substance by High Performance Liquid Chromatography
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

[+]

urn:sha256:55fb3c66cf8bde76feedd81db15d4a08226e2c35e92baa69c196ae8e6745016b
Download URL:

https://rosap.ntl.bts.gov/view/dot/21391/dot_21391_DS1.pdf
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The Identification and Quantitation of Triamterene in Blood and Urine from a Fatal Aircraft Accident

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