Development of electrophysiological indices of neurological toxicity for organophosphate pesticides and depressant drugs.

Revzin, A.M.; Civil Aeromedical Institute

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Development of electrophysiological indices of neurological toxicity for organophosphate pesticides and depressant drugs.

1979-05-01
By Revzin, A.M.

[PDF-1.26 MB]

English

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Details:

Creators:

Revzin, A.M.
Corporate Creators:

Civil Aeromedical Institute
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:

[+]

Aerial Application Alcohol Effects Amphetamines Antihistamines Behavior Behavioral Toxicology Birds Brain Brain--Effect Of Drugs On Chlorpromazine Drug Effects Laboratory Animals Laboratory Tests Organophosphorus Compounds Pest Control Baits--Aerial Application Pesticides Pesticides--Risk Assessment Risk Assessment Toxicology Vision
Publication/ Report Number:

FAA-AM-79-15 ; DOT/FAA/AM-79/15

FAA-AM-79-15 ; DOT/FAA/AM-79/15 Less -
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

Accurate control of eye movements and rapid detection of unexpected events in the periphery of the visual field are critically important in the aviation environment. We have studied the effects of certain drugs and environmental pollutants on brain mechanisms controlling these visual reflexes, using single nerve cell recordings in animal model systems. Most agents studied deleteriously affected reflex functions at extremely low doses. This was especially true for organophosphate pesticides, related cholinergic compounds, and ethyl alcohol. Some drugs, such as imipramine and amphetamine, seemed to have little deleterious effect.

Overall, the results suggest that some drugs and environmental pollutants can impair visual functions at doses not normally considered hazardous, and thus indicate the need for extreme caution in evaluating the safety margins of such materials in aviation medicine.
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

[+]

urn:sha256:4eac1341fca5158e817a13c444185e64e07b70aef0f6d582944ecef0ac52d88b
Download URL:

https://rosap.ntl.bts.gov/view/dot/21166/dot_21166_DS1.pdf
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Development of electrophysiological indices of neurological toxicity for organophosphate pesticides and depressant drugs.

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