Assessment of factors possibly contributing to the susceptibility of sickle trait erythrocytes to mild hypoxia. I., Design considerations and research protocol.

McKenzie, Jess M.; Civil Aeromedical Institute

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Assessment of factors possibly contributing to the susceptibility of sickle trait erythrocytes to mild hypoxia. I., Design considerations and research protocol.

1978-08-01
By McKenzie, Jess M.

[PDF-545.16 KB]

English

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Details:

Creators:

McKenzie, Jess M.
Corporate Creators:

Civil Aeromedical Institute
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:

[+]

Blood--Analysis Blood Analysis Cerebral Anoxia Certification Design Methods Diseases And Medical Conditions Experimental Design Flight Crews--Certification Flight Personnel Hemoglobin Human Subject Testing Hypoxia Kidneys Methodology Sickle Cell Anemia--Diagnosis--Methodology Stress (Physiology) Urine Urine--Analysis
Publication/ Report Number:

FAA-AM-78-30 ; DOT/FAA/AM-78/30

FAA-AM-78-30 ; DOT/FAA/AM-78/30 Less -
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

This report continues a review (see FAA-AM-76-15) of the evidence for mixed dominance of the Hbs beta gene in people with the sickle cell trait. These individuals, whose erythrocytes contain a mixture of hemoglobins (HbA/HbS), are healthy and have a normal life expectancy. They are tolerant to moderate altitudes; their erythrocytes become sickled only at oxygen tensions that would be hazardous to any person.

However, there is a possibility that other debilitating factors (e.g., alcoholism, pulmonary disorders) can, in a small fraction of those with the trait, produce an abnormal susceptibility to hypoxia. Those so debilitated would not be medically qualified to serve as air crewmembers. This report presents an experimental plan for estimating the proportion of such individuals in a population of young people with the sickle trait and outlines methods to be used in the study.
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

[+]

urn:sha256:d40307f2c78b4d1fd5da18ad762f55f2ebdb46c160465ed7685f27c3ff811de1
Download URL:

https://rosap.ntl.bts.gov/view/dot/21140/dot_21140_DS1.pdf
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Assessment of factors possibly contributing to the susceptibility of sickle trait erythrocytes to mild hypoxia. I., Design considerations and research protocol.

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