Radiobiological aspects of high altitude flight : relative biological effectiveness of fast neutrons in suppressing immune capacity to an infective agent.

Details

• Creators:
  Friedberg, Wallace ; Neas, Barbara R. ; Faulkner, Donald N. ; Hannenman, Gerald D. ; Darden, E.B.
• Corporate Creators:
  Civil Aeromedical Institute
• Corporate Contributors:
  United States. Office of Aviation Medicine
• Subject/TRT Terms:
  • Altitude
  • Aviation safety
  • Cosmic rays
  • Solar radiation
  • Neutrons
  • Health
  • X rays
  • Laboratory animals
  • Rats
  • Laboratory tests
  More +
• Publication/ Report Number:
  FAA-AM-78-8 ; DOT/FAA/AM-78/8
• Resource Type:
  Tech Report
• Geographical Coverage:
  United States
• Corporate Publisher:
  Civil Aerospace Medical Institute
• Abstract:
  We investigated the relative biological effectiveness (RBE) of fast neutrons compared with X-rays in impeding development of immunity to an infective agent, the intestinal cestode Hymenolepis nana. Mice were irradiated with neutrons or X-rays and 2 days later given an immunizing dose of H. nana eggs. After another 2 days, the mice received a challenge dose of the eggs. Challenge egg doses were also given to sham-irradiated unimmunized and immunized controls. ; All mice were killed 90 to 92 hours after challenge, and the H. nana larvae (cysticercoids) that developed in the intestinal tissue were counted. An increased cysticercoid count in the irradiated mice, as compared with the count in unirradiated immunized controls, reflects suppression of immune capacity by the radiation. The results indicate a neutron RBE of 4 at 50 and 101 rad.
• Format:
  PDF
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/21118/dot_21118_DS1.pdf
• File Type:
  [PDF - 232.30 KB]
• Collection(s):
  US Transportation Collection ; FAA Civil Aerospace Medical Institute
• Main Document Checksum:
  urn:sha-512:3367d1e696cfb48970888ea46c3afbea5150a35fdaf57f3481a9c57fc0f76096ae9a027c56d1f8fbdb5781a9b6fd4fd98af4876deb58c15c37917b35fa809be2