United States Department of Transportation
i
The role of monamine oxidase inhibition in the acute toxicity of chlordimeform.
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1977-08-01
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[PDF-434.52 KB]
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Abstract:This paper presents data from experiments on male rats performed to determine whether drugs which interfere with central amine mechanisms would decrease the lethality of the acaricide chlordimeform (and thus be of potential value as antidotes for accidental poisoning) or increase chlordimeform lethality (and thus should be avoided by aerial applicators and others in contact with it).
Neither reducing serotonin synthesis with p-chlorophenylalanine, raducing norepinephrine synthesis with DL-alpha-methyl-p-tyrosine nor depleting both amines with reserpine affected the lethality of chlordimeform. Likewise, blocking alpha-adrenergic receptors with phentolamine or the serotonergic receptors with methysergide, or both, did not influence chlordimeform lethality. The adrenergic agonist drug phenylephrine also did not affect chlordimeform lethality.
Thus, the results indicate that:
1.monamine oxidase inhibition does not play a major role in acute chlordimeform lethality;
2.none of the drugs tested shows promise in the treatment of chlordimeform poisoning, and
3.aerial applicators or others would appear to incur little or no extra risk should they be taking any of the above drugs during potential exposure to chlordimeform.
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