Effects of lithium carbonate on performance and biomedical functions.

Details

• Creators:
  Higgins, E. ; Chiles, W. ; McKenzie, J. ; Davis, A. ; Funkhouser, G. ; Jennings, A. ; Mullen, S. ; Fowler, P.
• Corporate Creators:
  Civil Aeromedical Institute
• Corporate Contributors:
  United States. Office of Aviation Medicine
• Subject/TRT Terms:
  • Lithium
  • Carbonates
  • Drug effects
  • Physiological aspects
  • Performance
  • Motor reactions
  • Urine
  • Heart rate
  • Memory
  • Stress (Physiology)
  More +
• Publication/ Report Number:
  FAA-AM-77-17 ; DOT/FAA/AM-77/17
• Resource Type:
  Tech Report
• Geographical Coverage:
  United States
• Corporate Publisher:
  Civil Aerospace Medical Institute
• Abstract:
  The effects of a single 600-mg dose of lithium carbonate were evaluated in a study of 15 healthy, normal male subjects. Subjects were studied, on two occasions, by utilizing a double-blind design--once receiving the lithium carbonate and once receiving a lactose placebo. ; Measurements were made of ; 1.complex performance, using the CAMI Multiple Task Performance Battery, ; 2.hand steadiness, using the steadiness tester of the Motor Steadiness Kit, ; 3.heart rate, ; 4.the urinary excretion of 17-ketogenic steroids, epinephrine, and norepinephrine, and ; 5.short term memory, as measured by the Wechsler Memory Scale. ; The only statistically significant effect due to the drug was for short term memory, in which scores made by subjects taking the placebo were higher than scores made by those taking the lithium carbonate.
• Format:
  PDF
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/21110/dot_21110_DS1.pdf
• File Type:
  [PDF - 1.23 MB]
• Collection(s):
  US Transportation Collection ; FAA Civil Aerospace Medical Institute
• Main Document Checksum:
  urn:sha-512:615f06903ea605c5559876501949771e2ee33047b2ff27c71c2e02853200427e2614f8e2816f7a328ae10e412f54c43ef0634dfbc970c8013a10eff8a1996288