Effects of lithium carbonate on performance and biomedical functions.

Higgins, E.; Chiles, W.; McKenzie, J.; Davis, A.; Funkhouser, G.; Jennings, A.; Mullen, S.; Fowler, P.; Civil Aeromedical Institute

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Effects of lithium carbonate on performance and biomedical functions.

1977-07-01
By Higgins, E. ; Chiles, W. ; McKenzie, J. ; ...

[PDF-1.23 MB]

English

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Creators:

Higgins, E. ; Chiles, W. ; McKenzie, J. ; Davis, A. ; Funkhouser, G. ; ... More +

Higgins, E. ; Chiles, W. ; McKenzie, J. ; Davis, A. ; Funkhouser, G. ; Jennings, A. ; Mullen, S. ; Fowler, P. Less -
Corporate Creators:

Civil Aeromedical Institute
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:

[+]

Adrenaline Air Pilots Air Pilots--Effect Of Drugs On Amines Blood--Analysis Blood Analysis Carbonates Catecholamines Depression (Mental Condition) Depression, Mental Drug Effects Experiments Heart Beat Heart Rate Human Subject Testing Lithium Lithium Compounds Memory Motor Ability Motor Reactions Noradrenaline Performance Physiological Aspects Short-term Memory Stress (Physiology) Urine Urine--Analysis
Publication/ Report Number:

FAA-AM-77-17 ; DOT/FAA/AM-77/17

FAA-AM-77-17 ; DOT/FAA/AM-77/17 Less -
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

The effects of a single 600-mg dose of lithium carbonate were evaluated in a study of 15 healthy, normal male subjects. Subjects were studied, on two occasions, by utilizing a double-blind design--once receiving the lithium carbonate and once receiving a lactose placebo.

Measurements were made of

1.complex performance, using the CAMI Multiple Task Performance Battery,

2.hand steadiness, using the steadiness tester of the Motor Steadiness Kit,

3.heart rate,

4.the urinary excretion of 17-ketogenic steroids, epinephrine, and norepinephrine, and

5.short term memory, as measured by the Wechsler Memory Scale.

The only statistically significant effect due to the drug was for short term memory, in which scores made by subjects taking the placebo were higher than scores made by those taking the lithium carbonate.
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

[+]

urn:sha256:9ef0df70881e5e684838af023db9aaf33af7ebd1924edade5ae8e32abedd3750
Download URL:

https://rosap.ntl.bts.gov/view/dot/21110/dot_21110_DS1.pdf
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Effects of lithium carbonate on performance and biomedical functions.

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