Effects of ethanol on visual unit activity in the thalamus.

Revzin, A.M.; Civil Aeromedical Institute

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ROSA P serves as an archival repository of USDOT-published products including scientific findings, journal articles, guidelines, recommendations, or other information authored or co-authored by USDOT or funded partners. As a repository, ROSA P retains documents in their original published format to ensure public access to scientific information.

i

Effects of ethanol on visual unit activity in the thalamus.

1978-01-01
By Revzin, A.M.

English

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Details:

Creators:

Revzin, A.M.
Corporate Creators:

Civil Aeromedical Institute
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:

[+]

Alcohol--Physiological Effect Alcohol Effects Birds Birds As Laboratory Animals Brain Dosage Ethanol Laboratory Animals Peripheral Vision Physiological Aspects Thalamus Toxicology Vision
Publication/ Report Number:

FAA-AM-78-2 ; DOT/FAA/AM-78/2

FAA-AM-78-2 ; DOT/FAA/AM-78/2 Less -
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

The investigator studied the effects of ethanol on the spontaneous activity of single neurons in functionally differentiated subnuclei of a posterior thalamic visual projection area, nucleus rotundus, in the anesthetized pigeon. Low doses of ethanol, 0.05 - 0.10 ml/kg (producing blood levels of about 0.005 - 0.010%) , inhibited activity in anterior rotundus but had complex excitatory-inhibitory effects on posterior rotundal cells. Nonvisual dorsal thalamic cells, and 'lateral geniculate' neurons were inhibited by ethanol but threshold doses (0.25 - 0.40 ml/kg) were far higher than those for the rotundal cells (0.05 ml/kg).

These differing dose-response curves for visual and nonvisual thalamic neurons suggest:

1.low doses of ethanol may seriously impair peripheral visual functions;

2.The behavioral effects of ethanol are highly dose-dependent;

3.Effects of low doses of ethanol may not be extrapolated from high-dose effects since high-dose effects may mask effects dominant at low doses;

4.The effects of a given dose of ethanol may vary widely and unpredictably among individuals.

Thus, the notorious unpredictability of ethanol-induced changes in behavior or task performance may be the inevitable consequence of the reported differential dose-response effects on single neurons.
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

[+]

urn:sha256:ed19c378b8825e8529552368e3ae1ecc23aee3ca1be40bccfd1e5893de140a18
Download URL:

https://rosap.ntl.bts.gov/view/dot/21094/dot_21094_DS1.pdf
File Type:

[PDF-394.41 KB]