Subtle changes in brain functions produced by single doses of mevinphos (Phosdrin).

Details

• Creators:
  Revzin, Alvin M.
• Corporate Creators:
  Civil Aeromedical Institute
• Corporate Contributors:
  United States. Office of Aviation Medicine
• Subject/TRT Terms:
  • Aerial application
  • Air pilots
  • Pesticides
  • Esters
  • Brain
  • Physiological aspects
  • Nervous system
  • Alertness
  • Electrodes
  • Poisoning
  More +
• Publication/ Report Number:
  FAA-AM-73-3 ; DOT/FAA/AM-73/3
• Resource Type:
  Tech Report
• Geographical Coverage:
  United States
• Corporate Publisher:
  Civil Aerospace Medical Institute
• Abstract:
  Mevinphos (Phosdrin) was found to inhibit the amplitude of hippocampal evoked potentials in unanesthetized squirrel monkeys with chronically indwelling electrodes. The threshold dose was 0.050 mg/kg and the maximal dose studied was 0.200 mg/kg. Doses above 0.200 mg/kg induced hippocampal seizures. ; Within the dose range of 0.050 mg/kg to 0.200 mg/kg the amplitude and duration of the inhibition were directly proportional to dose. No peripheral signs of poisoning, such as tremor or salivation, were seen at doses of 0.200 mg/kg or under. The discussion emphasizes that mevinphos produces changes in brain function in the absence of the peripheral symptomatology usually taken as indicators of poisoning by aerial applicator personnel. ; Therefore, it is concluded that exposure to mevinphos may be unexpectedly hazardous since the aerial applicators may be unaware that they have been poisoned.
• Format:
  PDF
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/21017/dot_21017_DS1.pdf
• File Type:
  [PDF - 458.79 KB]
• Collection(s):
  FAA Civil Aerospace Medical Institute ; US Transportation Collection
• Main Document Checksum:
  urn:sha-512:8b7d3a7d52cff7c95d7f9d247bd22a49c2fd7fede6734e5a38a4c6c3fbfd0a9fb6c1b446580e41a1d9d7aaff3b03066338794d4f7a93ed241a1d0720b7893041