Subtle changes in brain functions produced by single doses of mevinphos (Phosdrin).

Revzin, Alvin M.; Civil Aeromedical Institute

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Subtle changes in brain functions produced by single doses of mevinphos (Phosdrin).

1973-02-01
By Revzin, Alvin M.

[PDF-458.79 KB]

English

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Creators:

Revzin, Alvin M.
Corporate Creators:

Civil Aeromedical Institute
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:

[+]

Aerial Application Air Pilots Alertness Brain Central Nervous System Cholinesterase Inhibitors Convulsions Electrodes Esters Experiments Hippocampus (Brain) Laboratory Animals Mevinphos Monkeys Monkeys As Laboratory Animals Nerves Nervous System Organophosphorus Compounds Pest Control Baits--Aerial Application Pesticides Pesticides--Physiological Effect Physiological Aspects Poisoning
Publication/ Report Number:

FAA-AM-73-3 ; DOT/FAA/AM-73/3

FAA-AM-73-3 ; DOT/FAA/AM-73/3 Less -
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

Mevinphos (Phosdrin) was found to inhibit the amplitude of hippocampal evoked potentials in unanesthetized squirrel monkeys with chronically indwelling electrodes. The threshold dose was 0.050 mg/kg and the maximal dose studied was 0.200 mg/kg. Doses above 0.200 mg/kg induced hippocampal seizures.

Within the dose range of 0.050 mg/kg to 0.200 mg/kg the amplitude and duration of the inhibition were directly proportional to dose. No peripheral signs of poisoning, such as tremor or salivation, were seen at doses of 0.200 mg/kg or under. The discussion emphasizes that mevinphos produces changes in brain function in the absence of the peripheral symptomatology usually taken as indicators of poisoning by aerial applicator personnel.

Therefore, it is concluded that exposure to mevinphos may be unexpectedly hazardous since the aerial applicators may be unaware that they have been poisoned.
Format:

PDF
Collection(s):

FAA Civil Aerospace Medical Institute US Transportation Collection
Main Document Checksum:

[+]

urn:sha256:d1ce13163ee5912c289e25c85d9adb76a18a7742a02b29d4ef4bf94b5a304975
Download URL:

https://rosap.ntl.bts.gov/view/dot/21017/dot_21017_DS1.pdf
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Subtle changes in brain functions produced by single doses of mevinphos (Phosdrin).

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