The data presented in the paper suggest that aerial applicator personnel exposed to endrin may be subject to two hitherto underfined toxic risks:
1.sensory disturbances which may appear after acute exposure at doses too low to produce tremors and other gross signs of posioning;
2.under some circumstances, endrin stored in body fat may be released in amounts sufficient to cause poisoning.
The effects of endrin on the brain were determined in anesthetized pigeons and in non-anesthetized squirrel monkeys with chronically implanted electrodes. In the pigeon, endrin (0.5 mg/kg) selectively affected neuronal excitability in a visual projection pathway homologous to the recently described Nucleus Lateralis Posterior Thalami--Inferior Temporal Gyrus visual system in the higher mammals. Endrin was administered chronically to the squirrel monkeys. Electroencephalographic changes occurred at dose levels which were approximately 25% those which induced tremors, seizures and the other signs generally considered pathognomonic for endrin poisoning. Three months after endrin administration was stopped, seizures could be induced in the poisoned monkeys in a 'stress' situation.
Links with this icon indicate that you are leaving a Bureau of Transportation
Statistics (BTS)/National Transportation Library (NTL)
Web-based service.
Thank you for visiting.
You are about to access a non-government link outside of
the U.S. Department of Transportation's National
Transportation Library.
Please note: While links to Web sites outside of DOT are
offered for your convenience, when you exit DOT Web sites,
Federal privacy policy and Section 508 of the Rehabilitation
Act (accessibility requirements) no longer apply. In
addition, DOT does not attest to the accuracy, relevance,
timeliness or completeness of information provided by linked
sites. Linking to a Web site does not constitute an
endorsement by DOT of the sponsors of the site or the
products presented on the site. For more information, please
view DOT's Web site linking policy.
To get back to the page you were previously viewing, click
your Cancel button.
United States Department of Transportation
[PDF-804.82 KB]