Exploratory Development of Biomarkers for Neurobehavioral Performance Impairment During Sleep Loss: Comparison Across Multiple Types of Sleep Deprivation

Details

• Creators:
  Uyhelji, Hilary A ; Nicholson, Scott J. ; Nesthus, Thomas E. ; Beckel, Julia L ; Klerman, Elizabeth B ; Czeisler, Charles ; Yuan, Robin K ; Arrona-Palacios, Arturo ; Song, Pamela ; Ronda, Joseph M ; Sullivan, Jason P ; Goodson, Michael S
• Corporate Creators:
  United States. Department of Transportation. Federal Aviation Administration. Civil Aerospace Medical Institute ; Brigham and Women’s Hospital. Division of Sleep and Circadian Disorders ; Harvard Medical School. Division of Sleep Medicine ; Inje University College of Medicine. Department of Neurology ; United State Air Force Research Laboratory. Wright Patterson Air Force Base
• Corporate Contributors:
  United States. Department of Transportation. Federal Aviation Administration. Office of Aviation. Office of Aerospace Medicine
• Subject/TRT Terms:
  Aviation Safety Behavior Drowsiness Fatigue (Physiological Condition) Gene Expression Biomarkers Human Subject Testing Neurology Neurobehavioral Performance Impairment Psychomotor Vigilance Test Shifts Sleep Sleep Deprivation

  More +
• Publication/ Report Number:
  DOT/FAA/AM- 25/08
• DOI:
  https://doi.org/10.21949/1529683
• Resource Type:
  Manuscript
• Geographical Coverage:
  United States
• Edition:
  Manuscript
• Corporate Publisher:
  United States. Department of Transportation. Federal Aviation Administration. Office of Aviation. Office of Aerospace Medicine
• Abstract:
  Inter-individual variation in response to insufficient or altered timing of sleep presents a challenge for the development of personalized approaches to fatigue monitoring and mitigation. Besides health impacts, insufficient sleep can result in impaired neurobehavioral performance and pose a substantial risk of injury and even mortality in safety-critical operations such as transportation. The present study provides a detailed exploration of physiological, neurobehavioral, and gene expression changes during sleep restriction, acute total sleep deprivation, and altered timing of sleep among 59 healthy volunteer participants who completed a 10-day inpatient study.
• Content Notes:
  Final Peer Reviewed version citation: Uyhelji, H.A., Nicholson, S.J., Nesthus, T.E. et al. Exploratory development of biomarkers for neurobehavioral performance impairment during sleep loss: comparison across multiple types of sleep deprivation. BMC Genomics 26, 1043 (2025). https://doi.org/10.1186/s12864-025-12193-6
• Format:
  PDF
• Funding:
  FAA Contract 6973GH-22-D-00066, FAA Contract 6973GH-19-D-00066
• Collection(s):
  FAA Civil Aerospace Medical Institute
• Main Document Checksum:
  urn:sha-512:0a06adc387651be67f699e348c0152bca96d01aaaaf289ba58973962c258c887fb77e46d4ff997dc020d51b3e307705bc834127e84665cfd82b1a3e364c45dab
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/82949/dot_82949_DS1.pdf
• File Type:
  [PDF - 1.80 MB ]