Details:

Creators:
Slater, David ; Slater, Zoryanna [Zory] ; Bapat, Sanika ; Bradbury, Felix
Slater, David ; Slater, Zoryanna [Zory] ; Bapat, Sanika ; Bradbury, Felix Less -
Corporate Creators:
Mitre Corporation
Corporate Contributors:
United States. Department of Transportation. Federal Aviation Administration. Office of Aviation. Office of Aerospace Medicine
Subject/TRT Terms:
[+]
Aviation Medicine Aviation Safety Certification Coding Systems Data Files Risk Management Safety Management
DOI:
https://doi.org/10.21949/1529627
Resource Type:
Analytic Code
Geographical Coverage:
United States
Corporate Publisher:
United States. Department of Transportation. Federal Aviation Administration. Office of Aviation. Office of Aerospace Medicine
Abstract:
The Federal Aviation Administration (FAA) Office of Aerospace Medicine requires comprehensive longitudinal healthcare datasets to augment internal data for the purpose of conducting safety risk assessments to update medical standards (i.e. data driven, risk based decision making). The Federal Aviation Administration (FAA) tasked The MITRE Corporation’s Center for Advanced Aviation System Development (MITRE CAASD), in its Innovation Partner role, to identify commercial healthcare datasets that hold potential value in forecasting medical risk and are suitable for integration into the Aeromedical Data Environment. MITRE CAASD performed a market survey of existing healthcare datasets available commercially or for public use. This market survey led to the identification of over 40 healthcare data sources, many of which contain numerous subordinate sets. An initial set of screening criteria ensured that candidate data sources were sufficiently suitable for modeling objectives; this screening reduced the set to three final candidate data sources. These three data sources were compared using a set of features relevant to risk modeling of aeromedically relevant outcomes by condition. This set of comparison features included their coverage of medical conditions of interest to the FAA, as well as factors impacting integration into the aeromedical data environment.

The Federal Aviation Administration (FAA) Office of Aerospace Medicine is responsible for the medical certification of pilots such that the risk of pilot acute incapacitation is below a target risk threshold. This study sought to design a repeatable method of using commercial healthcare datasets to segment pilots with existing chronic conditions into acute incapacitation risk groups for the purpose of informing medical standards and certification policy guidance. Based on availability to the researchers, Merative’s Explorys electronic health record dataset, comprising 11 years of data, was used for method development. In collaboration with FAA medical officers, researchers operationalized pilot acute incapacitation as a composite outcome of 16 medical conditions and their associated diagnostic codes. These conditions were identified based on the scenario that a pilot is medically qualified to fly, conducts an adequate preflight self-assessment, and during flight experiences the acute onset of a state incompatible with active aircraft control such that orderly transfer of control to another pilot or automation is unlikely. Approaches to developing quantitative risk models for the outcome of pilot acute incapacitation were explored for four chronic conditions: diabetes, obstructive sleep apnea, chronic obstructive pulmonary disease, and atrial fibrillation. Three general approaches were explored: whole population risk, disease severity models, and a de novo method. Using whole-population risk resulted in over- and - underestimation of pilot acute incapacitation risk for a significant portion of the population. Using existing disease severity scores produced poor risk stratification for pilot acute incapacitation. The de novo method was designed to be broadly applicable to any condition of interest. The method was comprised of the following steps: (1) define the cohort for the condition of interest; (2) use a clinical reference tool (DynaMed, UpToDate, etc.) to produce relevant clinical factors; (3) use a clinical mapping tool (e.g., Unified Medical Language System) to link clinical factors to medical codes; (4) use information gain to select risk factors (relevant to both the chronic condition of interest and the outcome) from clinical factors for inclusion in pilot acute incapacitation risk models; (5) compute stratified incidence rates for pilot acute incapacitation; and (5) compare incident rates to the target risk threshold.

The code repository described below contains the SQL and python code for utilizing the Explorys EHR dataset to

1. Compute stratified incidence rates for aeromedically relevant conditions

2. Construct machine learning models to predict changes in risk categories


Format:
PDF
Funding:
693KA8-22-C-00001
Collection(s):
FAA Civil Aerospace Medical Institute
Main Document Checksum:
[+]
urn:sha256:91e759e5f70cfcb72e0270ba9e58909d7403903e003eadf861f8d444e64e69e3
Download URL:
https://rosap.ntl.bts.gov/view/dot/72389/dot_72389_DS1.pdf
File Type:

Supporting Files

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