A comparison of some effects of three antimotion sickness drugs on nystagmic responses to angular accelerations and to optokinetic stimuli.

Details

• Creators:
  Collins, William E. ; Schroeder, David J. ; Elam, Gary W.
• Corporate Creators:
  Civil Aeromedical Institute
• Corporate Contributors:
  United States. Office of Aviation Medicine
• Subject/TRT Terms:
  • Motion sickness
  • Drugs
  • Drug effects
  • Eye fixations
  • Eye location
  • Eye movements
  • Vision
  • Vision tests
  • Depth perception
  • Motion perception
  More +
• Publication/ Report Number:
  FAA-AM-81-16 ; DOT/FAA/AM-81/16
• Resource Type:
  Tech Report
• Geographical Coverage:
  United States
• Corporate Publisher:
  Civil Aerospace Medical Institute
• Abstract:
  This study examined the influence of three established antimotion sickness drugs on nystagmic eye movement responses to angular acceleration (whole-body movement) with vision either permitted or denied, and to optokinetic stimulation (visual field movement). ; Dimenhydrinate and promethazine hydrochloride, particularly at higher dose levels, reduced optokinetic nystagmus, thereby making less accurate the following ability of the eye. During whole-body motion in darkness, there was little placebo-drug difference in the vestibular response under alert conditions; under relaxed conditions, dimenhydrinate and promethazine hydrochloride produced significant declines in the vestibular eye movements. ; These same drugs also interfered with the ability of the individual to fixate adequately on a visual task during motion. Subjects who received a combination of promethazine plus d-amphetamine were able to suppress vestibular eye movements under the task condition and maintain good visual fixation. ; Thus, the effect of a drug on nystagmus may be a poor indicator of its value in preventing motion sickness. Moreover, assessments of antimotion sickness drugs for many practical situations should include as a possible adverse side effect the inability to maintain visual fixation during motion.
• Format:
  PDF
• Download URL:
  https://rosap.ntl.bts.gov/view/dot/21197/dot_21197_DS1.pdf
• File Type:
  [PDF - 822.51 KB]
• Collection(s):
  US Transportation Collection ; FAA Civil Aerospace Medical Institute
• Main Document Checksum:
  urn:sha-512:4e72ad02e0ffbe45b10ac175533d4a05b34159333b949b288d909c7f77c3de0899b566f7e6863b7df82923e64f36c05421897f58c2ebc7ae57ebe7ef4d26ef4a