The mechanisms of intrarenal hemodynamic changes following acute arterial occlusion.

Hinshaw, Lerner B.; Pace, Barbara B.; Brake, Charles M.; Amerson, Thomas E.; Masucci, Frederick D.

i

The mechanisms of intrarenal hemodynamic changes following acute arterial occlusion.

1963-10-01
By Hinshaw, Lerner B. ; Pace, Barbara B. ; Brake, Charles M.

File Language:

English

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Creators:

Hinshaw, Lerner B. ; Pace, Barbara B. ; Brake, Charles M. ; Amerson, Thomas E. ; Masucci, Frederick D.
Corporate Creators:

Civil Aeromedical Research Institute. Aeronautical Center
Corporate Contributors:

United States. Office of Aviation Medicine
Subject/TRT Terms:
Publication/ Report Number:

AM 63-22 ; DOT/FAA/AM-63/22
Resource Type:

Tech Report
Geographical Coverage:

United States
Corporate Publisher:

Civil Aerospace Medical Institute
Abstract:

The hemodynamic response of the kidney to acute arterial occlusion is poorly understood. The purpose of the present study was to determine intrarenal hemodynamic changes in intact and isolated kidneys following arterial occlusion. ; The relative roles of metabolic, myogenic and tissue pressure influences on the post-occlusion response were evaluated. The illegible of the kidney to occlusion was found to be complex depending on the interaction of a variety of physical and humoral forces. Increases in renal resistance appeared to be due in part to adrenergic agents and were enhanced by extending time of occlusion and lowering the arterial pressure. ; The combined effects of pre-venous dilation and illegible tissue pressure resulted in a decreased resistance following shorter periods of occlusion. Pre-venous dilation was accounted for by depressed vascular sensitivity to illegible agents and the presence of vasodilator substances. Changes in venous illegible resistance were found to be of primary importance in both the autoregulatory phenomenon and the post=occlusion hyperemic response to short (fifteen second) occlusion periods.
Format:

PDF
Download URL:

https://rosap.ntl.bts.gov/view/dot/20869/dot_20869_DS1.pdf
File Type:

[PDF - 917.26 KB]
Collection(s):

FAA Civil Aerospace Medical Institute ; US Transportation Collection
Main Document Checksum:

urn:sha-512:0ac50ee76dab3a5099dc5861e434ed4bcfd79e470d60547761d54ee8659ea93b04d0b787c8ed847b45f53ffe9b6095aa421e8592bc669dc336c1173578b5db3a

File Language:

English

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