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A Study Comparing the Hypnotic Efficacies and Residual Effects on Actual Driving Performance of Midazolam 15 mg, Triazolam 0.5 mg, Temazepam 20 mg and Placebo in Shiftworkers on Night Duty
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1988-11-01
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[PDF-3.27 MB]
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Abstract:The purpose of the study was to determine the hypnotic efficacy and residual effects of three hypnotics administered for the treatment of transient insomnia in the day-sleep of rotating shift workers. The average duration of day-sleep in rotating shift workers is 5 to 6 hours. Midazolam, triazolam and temazepam all possess short elimination half-lives, i.e. 2, 4 and 8 hours, respectively. This suggests that these drugs should be largely free from residual effects and therefore not impair performance in real-life tasks.
It was concluded that midazolam 15 mg can be recommended for use by rotating shift workers in order to cope with transient insomnia caused by poor adaptation to night-shift, and that in general no residual effects will be present 6.5 hours after ingestion. Temazepam 20 mg is less likely to improve day-sleep, but is absolutely free from residual sedative effects. Triazolam 0.5 mg can not be recommended because it is less likely to improve day-sleep and is unsafe to drive with 6.5-8.5 firs after ingestion.
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